Cargando…

Uncarboxylated Osteocalcin Decreases SCD1 by Activating AMPK to Alleviate Hepatocyte Lipid Accumulation

Uncarboxylated osteocalcin (GluOC), a small-molecule protein specifically synthesized and secreted by osteoblasts, is important in the regulation of energy metabolism. In our previous study, GluOC was shown to be effective in ameliorating dyslipidemia and hepatic steatosis in KKAy mice. However, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Danqing, Zhang, Miao, Xu, Jiaojiao, Yang, Jianhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095730/ https://www.ncbi.nlm.nih.gov/pubmed/37049884 http://dx.doi.org/10.3390/molecules28073121

Ejemplares similares

Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGF-β/SMAD3 signaling pathway
por: Xu, Jiaojiao, et al.
Publicado: (2022)

Smoking cessation increases levels of osteocalcin and uncarboxylated osteocalcin in human sera
por: Kiyota, Yasuhiro, et al.
Publicado: (2020)

Differential Roles of Carboxylated and Uncarboxylated Osteocalcin in Prostate Cancer Growth
por: Hayashi, Yoshikazu, et al.
Publicado: (2016)

Assessment of Uncarboxylated Osteocalcin Levels in Type 2 Diabetes Mellitus
por: Alamri, Taghreed M, et al.
Publicado: (2023)

Elevated Creatine Kinase and Lactic Acid Dehydrogenase and Decreased Osteocalcin and Uncarboxylated Osteocalcin are Associated with Bone Stress Injuries in Young Female Athletes
por: Miyamoto, Takeshi, et al.
Publicado: (2018)

Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway
por: Zhang, Xiao-lin, et al.
Publicado: (2019)

Uncarboxylated osteocalcin alleviates the inhibitory effect of high glucose on osteogenic differentiation of mouse bone marrow–derived mesenchymal stem cells by regulating TP63
por: Gong, Fangzi, et al.
Publicado: (2021)

Uncarboxylated Osteocalcin Induces Antitumor Immunity against Mouse Melanoma Cell Growth
por: Hayashi, Yoshikazu, et al.
Publicado: (2017)

Association between serum uncarboxylated osteocalcin levels and nutritional intake in Japanese female athletes
por: Ishizu, Tatsuya, et al.
Publicado: (2022)

Recombinant Antibodies with Unique Specificities Allow for Sensitive and Specific Detection of Uncarboxylated Osteocalcin in Human Circulation
por: Arponen, Milja, et al.
Publicado: (2020)

The Different Mechanisms of Lipid Accumulation in Hepatocytes Induced by Oleic Acid/Palmitic Acid and High-Fat Diet
por: Zhang, Miao, et al.
Publicado: (2023)

Uncarboxylated osteocalcin promotes osteogenesis and inhibits adipogenesis of mouse bone marrow-derived mesenchymal stem cells via the PKA-AMPK-SIRT1 axis
por: Gao, Le, et al.
Publicado: (2021)

Neurotropin Inhibits Lipid Accumulation by Maintaining Mitochondrial Function in Hepatocytes via AMPK Activation
por: Wang, Qinglan, et al.
Publicado: (2020)

Recombinant Uncarboxylated Osteocalcin Per Se Enhances Mouse Skeletal Muscle Glucose Uptake in both Extensor Digitorum Longus and Soleus Muscles
por: Lin, Xuzhu, et al.
Publicado: (2017)

FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling
por: Kong, Yezi, et al.
Publicado: (2022)

Osteocalcin reduces fat accumulation and inflammatory reaction by inhibiting ROS-JNK signal pathway in chicken embryonic hepatocytes
por: Zhang, M., et al.
Publicado: (2022)

Tschimganidine reduces lipid accumulation through AMPK activation and alleviates high-fat diet-induced metabolic diseases
por: Hwang, Min-Seon, et al.
Publicado: (2023)

Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes
por: Tanaka, Miori, et al.
Publicado: (2020)

The Role of Tea Tree Oil in Alleviating Palmitic Acid-Induced Lipid Accumulation in Bovine Hepatocytes
por: Yang, Tianyu, et al.
Publicado: (2022)

Zaluzanin C Alleviates Inflammation and Lipid Accumulation in Kupffer Cells and Hepatocytes by Regulating Mitochondrial ROS
por: Jung, Ji-Won, et al.
Publicado: (2023)

Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK
por: Huang, Qi, et al.
Publicado: (2017)

Bromide alleviates fatty acid‐induced lipid accumulation in mouse primary hepatocytes through the activation of PPARα signals
por: Shi, Yujie, et al.
Publicado: (2019)

Dehydroepiandrosterone alleviates oleic acid-induced lipid metabolism disorders through activation of AMPK-mTOR signal pathway in primary chicken hepatocytes
por: Yao, Yao, et al.
Publicado: (2022)

Osteocalcin Alleviates Lipopolysaccharide-Induced Acute Inflammation via Activation of GPR37 in Macrophages
por: Qian, Zhengjiang, et al.
Publicado: (2022)

Nonalcoholic Lipid Accumulation and Hepatocyte Malignant Transformation
por: Gu, Juanjuan, et al.
Publicado: (2016)

Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol
por: Foretz, Marc, et al.
Publicado: (2018)

Desphospho-Uncarboxylated Matrix-Gla Protein Is Increased Postoperatively in Cardiovascular Risk Patients
por: Dahlberg, Sofia, et al.
Publicado: (2018)

Hepatocyte growth factor alleviates hepatic insulin resistance and lipid accumulation in high‐fat diet‐fed mice
por: Jing, Yali, et al.
Publicado: (2018)

Osteocalcin levels decrease during the treatment of an acute depressive episode
por: Bartečků, Elis, et al.
Publicado: (2022)

The Peptide AWRK6 Alleviates Lipid Accumulation in Hepatocytes by Inhibiting miR-5100 Targeting G6PC
por: Liu, Jiaxin, et al.
Publicado: (2023)

Circulating Levels of Dephosphorylated-Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome
por: Bilalic, Admira, et al.
Publicado: (2021)

Dietary supplement of Smilax china L. ethanol extract alleviates the lipid accumulation by activating AMPK pathways in high-fat diet fed mice
por: Yang, Licong, et al.
Publicado: (2019)

SCD leads to the development and progression of acute myocardial infarction through the AMPK signaling pathway
por: Wang, Lijie, et al.
Publicado: (2021)

Limonin, an AMPK Activator, Inhibits Hepatic Lipid Accumulation in High Fat Diet Fed Mice
por: Wang, Si-wei, et al.
Publicado: (2022)

Quzhi Formula Alleviates Nonalcoholic Steatohepatitis by Impairing Hepatocyte Lipid Accumulation and Inflammation via Bip/eIF2α Signaling
por: Wu, Yue-Lan, et al.
Publicado: (2022)

SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes
por: Inoue, Chisato, et al.
Publicado: (2017)

Lotus Seedpod Extracts Reduced Lipid Accumulation and Lipotoxicity in Hepatocytes
por: Liu, Yen-Tze, et al.
Publicado: (2019)

Central Hemodynamics in Relation to Circulating Desphospho‐Uncarboxylated Matrix Gla Protein: A Population Study
por: Wei, Fang‐Fei, et al.
Publicado: (2019)

Paeonia lactiflora root decreases lipid accumulation through the induction of lipolysis and thermogenesis via AMPK activation in 3T3-L1 cells
por: Choi, Jeong Won, et al.
Publicado: (2023)

MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1
por: Zhang, Meiyuan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_p3hl4d24ur4tair7ha5vdafgq6