Atropostatin: Design and Total Synthesis of an Atropisomeric Lactone–Atorvastatin Prodrug

Atorvastatins play an important role in the inhibition of HMG-CoA reductase, an enzyme present in the liver that takes part in the biosynthesis of cholesterol. In this article, we report the total synthesis of a lactone–atorvastatin prodrug with additional atropisomeric features. Conformational and...

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Detalles Bibliográficos
Autores principales: Pecorari, Daniel, Mazzanti, Andrea, Mancinelli, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095771/
https://www.ncbi.nlm.nih.gov/pubmed/37049939
http://dx.doi.org/10.3390/molecules28073176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095771/
https://www.ncbi.nlm.nih.gov/pubmed/37049939
http://dx.doi.org/10.3390/molecules28073176

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