Design and Synthesis of 3-(β-d-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential

Glycogen phosphorylase (GP) is a key regulator of glucose levels and, with that, an important target for the discovery of novel treatments against type 2 diabetes. β-d-Glucopyranosyl derivatives have provided some of the most potent GP inhibitors discovered to date. In this regard, C-β-d-glucopyrano...

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Detalles Bibliográficos
Autores principales: Kun, Sándor, Mathomes, Rachel T., Docsa, Tibor, Somsák, László, Hayes, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095824/
https://www.ncbi.nlm.nih.gov/pubmed/37049768
http://dx.doi.org/10.3390/molecules28073005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095824/
https://www.ncbi.nlm.nih.gov/pubmed/37049768
http://dx.doi.org/10.3390/molecules28073005

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