Diastereoselective Synthesis of (–)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid via Morpholinone Derivatives

A simple and convenient synthesis of (–)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid is described, applying a combination of two synthetic methods: the Petasis reaction and Pomeranz–Fritsch–Bobbitt cyclization. The diastereomeric morpholinone derivative N-(2,2-diethoxyethyl)-3-(3,...

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Detalles Bibliográficos
Autores principales: Chrzanowska, Maria, Grajewska, Agnieszka, Rozwadowska, Maria D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095930/
https://www.ncbi.nlm.nih.gov/pubmed/37049962
http://dx.doi.org/10.3390/molecules28073200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095930/
https://www.ncbi.nlm.nih.gov/pubmed/37049962
http://dx.doi.org/10.3390/molecules28073200

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