Cargando…

Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development Approach

An evaluation of the expression and predictive significance of the MDM2 gene in brain lower-grade glioma (LGG) cancer was carried out using onco-informatics pipelines. Several transcriptome servers were used to measure the differential expression of the targeted MDM2 gene and search mutations and co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Biswas, Partha, Bibi, Shabana, Yousafi, Qudsia, Mehmood, Asim, Saleem, Shahzad, Ihsan, Awais, Dey, Dipta, Hasan Zilani, Md. Nazmul, Hasan, Md. Nazmul, Saleem, Rasha, Awaji, Aeshah A., Fahmy, Usama A., Abdel-Daim, Mohamed M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095937/ https://www.ncbi.nlm.nih.gov/pubmed/37049742 http://dx.doi.org/10.3390/molecules28072977

Ejemplares similares

Anatomy of Mdm2 and Mdm4 in evolution
por: Tan, Ban Xiong, et al.
Publicado: (2017)

Evaluation of Melongosides as Potential Inhibitors of NS2B-NS3 Activator-Protease of Dengue Virus (Serotype 2) by Using Molecular Docking and Dynamics Simulation Approach
por: Biswas, Partha, et al.
Publicado: (2022)

Identification of Effective and Nonpromiscuous Antidiabetic Drug Molecules from Penicillium Species
por: Saleem, Shahzad, et al.
Publicado: (2022)

Mouse models of Mdm2 and Mdm4 and their clinical implications
por: Xiong, Shunbin
Publicado: (2013)

Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells
por: Mrkvová, Zuzana, et al.
Publicado: (2019)

Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells
por: Huun, Johanna, et al.
Publicado: (2017)

The role of MDM2 and MDM4 in breast cancer development and prevention
por: Haupt, Sue, et al.
Publicado: (2017)

Chemical composition and pharmacological activities of Pisum sativum
por: Zilani, Md Nazmul Hasan, et al.
Publicado: (2017)

Interaction of human dynein light chain 1 (DYNLL1) with enterochelin esterase (Salmonella typhimurium) and protective antigen (Bacillus anthraci) might be the potential cause of human infection
por: Yousafi, Qudsia, et al.
Publicado: (2020)

Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
por: Morshed, A K M Helal, et al.
Publicado: (2023)

Regulation of p53: a collaboration between Mdm2 and MdmX
por: Pei, Dongsheng, et al.
Publicado: (2012)

Regulation of kidney development by the Mdm2/Mdm4–p53 axis
por: El-Dahr, Samir, et al.
Publicado: (2017)

Associations of MDM2 and MDM4 Polymorphisms with Early-Stage Breast Cancer
por: Bartnykaitė, Agnė, et al.
Publicado: (2021)

The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans
por: Coffill, Cynthia R., et al.
Publicado: (2016)

The Functional Roles of the MDM2 Splice Variants P2-MDM2-10 and MDM2-∆5 in Breast Cancer Cells
por: Huun, Johanna, et al.
Publicado: (2017)

Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish
por: Chua, J S, et al.
Publicado: (2015)

A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
por: Biswas, Partha, et al.
Publicado: (2022)

Length matters: C-terminal tails regulate Mdm2–MdmX complexes
por: Poyurovsky, Masha V.
Publicado: (2012)

MDM2, MDM4 and EGFR Amplifications and Hyperprogression in Metastatic Acral and Mucosal Melanoma
por: Forschner, Andrea, et al.
Publicado: (2020)

MDM4 Isoform Expression in Melanoma Supports an Oncogenic Role for MDM4-A
por: Alatawi, Abdullah, et al.
Publicado: (2021)

Hinokiflavone Inhibits MDM2 Activity by Targeting the MDM2-MDMX RING Domain
por: Ilic, Viktoria K., et al.
Publicado: (2022)

Mdm2 and MdmX RING Domains Play Distinct Roles in the Regulation of p53 Responses: A Comparative Study of Mdm2 and MdmX RING Domains in U2OS Cells
por: Egorova, Olga, et al.
Publicado: (2020)

A cohort study on the association of MDM2 SNP309 with lung cancer risk in Bangladeshi population
por: Reza, Hasan Al, et al.
Publicado: (2020)

MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation
por: Hirose, Mitsuaki, et al.
Publicado: (2014)

Green Metallic Nanoparticles: Biosynthesis to Applications
por: Chopra, Hitesh, et al.
Publicado: (2022)

Subtractive Proteomics and Immuno-informatics Approaches for Multi-peptide Vaccine Prediction Against Klebsiella oxytoca and Validation Through In Silico Expression
por: Yousafi, Qudsia, et al.
Publicado: (2021)

In Vivo Bioactivities of Hoya parasitica (Wall.) and In Silico Study against Cyclooxygenase Enzymes
por: Sarkar, Kishore Kumar, et al.
Publicado: (2022)

EDM and MDM measurements in LHCb
por: Aiola, Salvatore
Publicado: (2019)

Introducing MDM Policy & Practice
por: Schwartz, Alan J.
Publicado: (2016)

Mdm2: Open questions
por: Dobbelstein, Matthias, et al.
Publicado: (2020)

Identification of Novel and Safe Fungicidal Molecules against Fusarium oxysporum from Plant Essential Oils: In Vitro and Computational Approaches
por: Yousafi, Qudsia, et al.
Publicado: (2022)

Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival
por: Liu, Tao, et al.
Publicado: (2015)

MDM2–MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance
por: Moscetti, Ilaria, et al.
Publicado: (2016)

p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX
por: Levy, Robin, et al.
Publicado: (2019)

A Call for Explainer/Tutorial Articles and Changes to Manuscript Submission and Review at MDM and MDM P&P
por: Zikmund-Fisher, Brian J.
Publicado: (2020)

The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors
por: Kannan, Srinivasaraghavan, et al.
Publicado: (2019)

Revolutionizing anti-cancer drug discovery against breast cancer and lung cancer by modification of natural genistein: an advanced computational and drug design approach
por: Akash, Shopnil, et al.
Publicado: (2023)

Current Status Of Cosmological Mdm Models
por: Mikheeva, E V
Publicado: (2000)

Mdm2 pulls the plug on glycolysis
por: Short, Ben
Publicado: (2014)

Targeting MDM4 Splicing in Cancers
por: Bardot, Boris, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_o5mf93325t900kgj6t4stn1j4k