Menin–MLL1 Interaction Small Molecule Inhibitors: A Potential Therapeutic Strategy for Leukemia and Cancers

Encoded by the MEN1 gene, menin protein is a fusion protein that is essential for the oncogenic transformation of mixed-lineage leukemia (MLL) and leads to acute leukemia (AL). Therefore, accumulating evidence has demonstrated that inhibition of the high-affinity relationship between menin and mixed...

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Detalles Bibliográficos
Autores principales: Shi, Qing, Xu, Meiqi, Kang, Zhijian, Zhang, Manjie, Luo, Yakun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095982/
https://www.ncbi.nlm.nih.gov/pubmed/37049787
http://dx.doi.org/10.3390/molecules28073026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095982/
https://www.ncbi.nlm.nih.gov/pubmed/37049787
http://dx.doi.org/10.3390/molecules28073026

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