Shikonin Binds and Represses PPARγ Activity by Releasing Coactivators and Modulating Histone Methylation Codes

Shikonin, a natural ingredient produced by Lithospermum erythrorhizon, has anti-inflammatory, anti-cancer, and anti-obesity effects. It also inhibits adipocyte differentiation; however, the underlying molecular and epigenetic mechanisms remain unclear. We performed RNA-sequencing of shikonin-treated...

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Detalles Bibliográficos
Autores principales: Park, Ui-Hyun, Youn, HyeSook, Kim, Eun-Joo, Um, Soo-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097191/
https://www.ncbi.nlm.nih.gov/pubmed/37049636
http://dx.doi.org/10.3390/nu15071797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097191/
https://www.ncbi.nlm.nih.gov/pubmed/37049636
http://dx.doi.org/10.3390/nu15071797

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