Interactome dynamics of RAF1-BRAF kinase monomers and dimers

RAF kinases play major roles in cancer. BRAFV600E mutants drive ~6% of human cancers. Potent kinase inhibitors exist but show variable effects in different cancer types, sometimes even inducing paradoxical RAF kinase activation. Both paradoxical activation and drug resistance are frequently due to e...

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Detalles Bibliográficos
Autores principales: Iglesias-Martinez, Luis F., Rauch, Nora, Wynne, Kieran, McCann, Brendan, Kolch, Walter, Rauch, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Data Descriptor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097620/
https://www.ncbi.nlm.nih.gov/pubmed/37045861
http://dx.doi.org/10.1038/s41597-023-02115-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097620/
https://www.ncbi.nlm.nih.gov/pubmed/37045861
http://dx.doi.org/10.1038/s41597-023-02115-0

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