Cargando…

Flubendazole exhibits anti-glioblastoma effect by inhibiting STAT3 and promoting cell cycle arrest

Glioblastoma multiforme (GBM) belongs to most aggressive and invasive primary brain tumor in adults whose prognosis and survival remains poor. Potential new treatment modalities include targeting the cytoskeleton. In our study, we demonstrated that repurposed drug flubendazole (FLU) significantly in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vítovcová, Barbora, Skarková, Veronika, Havelek, Radim, Soukup, Jiří, Pande, Ananya, Caltová, Kateřina, Rudolf, Emil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097688/ https://www.ncbi.nlm.nih.gov/pubmed/37045903 http://dx.doi.org/10.1038/s41598-023-33047-9

Ejemplares similares

Author Correction: Flubendazole exhibits anti-glioblastoma effect by inhibiting STAT3 and promoting cell cycle arrest
por: Vítovcová, Barbora, et al.
Publicado: (2023)

Biology of Glioblastoma Multiforme—Exploration of Mitotic Catastrophe as a Potential Treatment Modality
por: Vitovcova, Barbora, et al.
Publicado: (2020)

Selected Aspects of Chemoresistance Mechanisms in Colorectal Carcinoma—A Focus on Epithelial-to-Mesenchymal Transition, Autophagy, and Apoptosis
por: Skarkova, Veronika, et al.
Publicado: (2019)

The Evaluation of Glioblastoma Cell Dissociation and Its Influence on Its Behavior
por: Skarkova, Veronika, et al.
Publicado: (2019)

Diagnostic Utility of Immunohistochemical Detection of MEOX2, SOX11, INSM1 and EGFR in Gliomas
por: Soukup, Jiri, et al.
Publicado: (2023)

Role of N-Cadherin in Epithelial-to-Mesenchymal Transition and Chemosensitivity of Colon Carcinoma Cells
por: Skarkova, Veronika, et al.
Publicado: (2022)

Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis
por: Zhou, Xumin, et al.
Publicado: (2018)

Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy
por: Lin, Shichong, et al.
Publicado: (2019)

Flubendazole as a macrofilaricide: History and background
por: Geary, Timothy G., et al.
Publicado: (2019)

Cardiac Troponins are Among Targets of Doxorubicin-Induced Cardiotoxicity in hiPCS-CMs
por: Adamcova, Michaela, et al.
Publicado: (2019)

Flubendazole Elicits Antitumor Effects by Inhibiting STAT3 and Activating Autophagy in Non-small Cell Lung Cancer
por: Xie, Xiaona, et al.
Publicado: (2021)

Metabolism of albendazole, ricobendazole and flubendazole in Haemonchus contortus adults: Sex differences, resistance-related differences and the identification of new metabolites
por: Stuchlíková, Lucie Raisová, et al.
Publicado: (2018)

Toxicity of anthelmintic drugs (fenbendazole and flubendazole) to aquatic organisms
por: Wagil, Marta, et al.
Publicado: (2014)

Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells
por: Habartova, Klara, et al.
Publicado: (2018)

Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions
por: Kubíček, Vladimír, et al.
Publicado: (2019)

Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers
por: Chen, Chaoran, et al.
Publicado: (2022)

Flubendazole inhibits PD-1 and suppresses melanoma growth in immunocompetent mice
por: Li, Yue, et al.
Publicado: (2023)

The effect of sodium butyrate and cisplatin on expression of EMT markers
por: Mrkvicova, Alena, et al.
Publicado: (2019)

The Effect of Chronic Exposure of Graphene Nanoplates on the Viability and Motility of A549 Cells
por: Šestáková, Blanka, et al.
Publicado: (2022)

Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells
por: Hou, Zhi-Jie, et al.
Publicado: (2015)

Profiling the macrofilaricidal effects of flubendazole on adult female Brugia malayi using RNAseq
por: O'Neill, Maeghan, et al.
Publicado: (2016)

Evaluation of Three Amorphous Drug Delivery Technologies to Improve the Oral Absorption of Flubendazole
por: Vialpando, Monica, et al.
Publicado: (2016)

Exploring the Potential of Flubendazole in Filariasis Control: Evaluation of the Systemic Exposure for Different Pharmaceutical Preparations
por: Ceballos, Laura, et al.
Publicado: (2014)

Exploring flubendazole formulations for use in sheep. Pharmacokinetic evaluation of a cyclodextrin-based solution
por: Ceballos, Laura, et al.
Publicado: (2012)

Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity
por: Tweats, David J., et al.
Publicado: (2016)

An In Vitro/In Vivo Model to Analyze the Effects of Flubendazole Exposure on Adult Female Brugia malayi
por: O’Neill, Maeghan, et al.
Publicado: (2016)

Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen
por: Michaelis, Martin, et al.
Publicado: (2015)

Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity
por: Tweats, David J, et al.
Publicado: (2018)

Synthesis, Antimycobacterial Activity and In Vitro Cytotoxicity of 5-Chloro-N-phenylpyrazine-2-carboxamides
por: Zitko, Jan, et al.
Publicado: (2013)

Mechanisms of Cell Cycle Arrest and Apoptosis in Glioblastoma
por: Gousias, Konstantinos, et al.
Publicado: (2022)

In vitro flubendazole-induced damage to vital tissues in adult females of the filarial nematode Brugia malayi
por: O'Neill, Maeghan, et al.
Publicado: (2015)

Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease
por: Nixon, Gemma L., et al.
Publicado: (2018)

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds
por: Hübner, Marc P., et al.
Publicado: (2019)

The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system
por: Risch, Frederic, et al.
Publicado: (2023)

The cytotoxic effect of α-tomatine in MCF-7 human adenocarcinoma breast cancer cells depends on its interaction with cholesterol in incubation media and does not involve apoptosis induction
por: SUCHA, LENKA, et al.
Publicado: (2013)

UMF-078: A modified flubendazole with potent macrofilaricidal activity against Onchocerca ochengi in African cattle
por: deC Bronsvoort, Barend M, et al.
Publicado: (2008)

Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and Their Cytotoxic Activity
por: Breiterová, Kateřina, et al.
Publicado: (2020)

In vitro and in vivo anticancer studies of 2'-hydroxy chalcone derivatives exhibit apoptosis in colon cancer cells by HDAC inhibition and cell cycle arrest
por: Pande, Aditya Narayan, et al.
Publicado: (2017)

Pancracine, a Montanine-Type Amaryllidaceae Alkaloid, Inhibits Proliferation of A549 Lung Adenocarcinoma Cells and Induces Apoptotic Cell Death in MOLT-4 Leukemic Cells
por: Koutová, Darja, et al.
Publicado: (2021)

Pharmacokinetic comparison of different flubendazole formulations in pigs: A further contribution to its development as a macrofilaricide molecule
por: Ceballos, L., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1k1h6fqifnuittligivgdtd8lm