DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors

Role of DNA damage and demethylation on anticancer activity of DNA methyltransferase inhibitors (DNMTi) remains undefined. We report the effects of DNMT1 gene deletion/disruption (DNMT1(−/−)) on anticancer activity of a class of DNMTi in vitro, in vivo and in human cancers. The gene deletion markedl...

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Detalles Bibliográficos
Autores principales: Laranjeira, Angelo B. A., Hollingshead, Melinda G., Nguyen, Dat, Kinders, Robert J., Doroshow, James H., Yang, Sherry X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097729/
https://www.ncbi.nlm.nih.gov/pubmed/37045940
http://dx.doi.org/10.1038/s41598-023-32509-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097729/
https://www.ncbi.nlm.nih.gov/pubmed/37045940
http://dx.doi.org/10.1038/s41598-023-32509-4

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