Expansion of circulating stem-like CD8(+) T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice

Combination of radiation therapy (RT) with immune checkpoint blockade can enhance systemic anti-tumor T cell responses. Here, using two mouse tumor models, we demonstrate that adding long-acting CD122-directed IL-2 complexes (IL-2c) to RT/anti-PD1 further increases tumor-specific CD8(+) T cell numbe...

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Detalles Bibliográficos
Autores principales: Onyshchenko, Kateryna, Luo, Ren, Guffart, Elena, Gaedicke, Simone, Grosu, Anca-Ligia, Firat, Elke, Niedermann, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097749/
https://www.ncbi.nlm.nih.gov/pubmed/37045833
http://dx.doi.org/10.1038/s41467-023-37825-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097749/
https://www.ncbi.nlm.nih.gov/pubmed/37045833
http://dx.doi.org/10.1038/s41467-023-37825-x

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