Cargando…

Expansion of circulating stem-like CD8(+) T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice

Combination of radiation therapy (RT) with immune checkpoint blockade can enhance systemic anti-tumor T cell responses. Here, using two mouse tumor models, we demonstrate that adding long-acting CD122-directed IL-2 complexes (IL-2c) to RT/anti-PD1 further increases tumor-specific CD8(+) T cell numbe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Onyshchenko, Kateryna, Luo, Ren, Guffart, Elena, Gaedicke, Simone, Grosu, Anca-Ligia, Firat, Elke, Niedermann, Gabriele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097749/ https://www.ncbi.nlm.nih.gov/pubmed/37045833 http://dx.doi.org/10.1038/s41467-023-37825-x

Ejemplares similares

Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING
por: Wang, Liqun, et al.
Publicado: (2023)

Chloroquine or Chloroquine-PI3K/Akt Pathway Inhibitor Combinations Strongly Promote γ-Irradiation-Induced Cell Death in Primary Stem-Like Glioma Cells
por: Firat, Elke, et al.
Publicado: (2012)

Non-Invasive In Vivo Imaging of Tumor-Associated CD133/Prominin
por: Tsurumi, Chizuko, et al.
Publicado: (2010)

Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57
por: Zhu, Xuekai, et al.
Publicado: (2014)

Imaging and Selective Elimination of Glioblastoma Stem Cells with Theranostic Near-Infrared-Labeled CD133-Specific Antibodies
por: Jing, Hua, et al.
Publicado: (2016)

Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990
por: Milanović, Dušan, et al.
Publicado: (2013)

Combination treatment with hypofractionated radiotherapy plus IL-2/anti-IL-2 complexes and its theranostic evaluation
por: Jing, Hua, et al.
Publicado: (2019)

Deep abscopal response to radiotherapy and anti-PD-1 in an oligometastatic melanoma patient with unfavorable pretreatment immune signature
por: Watanabe, Tsubasa, et al.
Publicado: (2020)

Delayed cell death associated with mitotic catastrophe in γ-irradiated stem-like glioma cells
por: Firat, Elke, et al.
Publicado: (2011)

$^{120}$Cd and $^{122}$Cd
por: Scheidemann, Ø, et al.
Publicado: (1973)

Circulating CD8(+)CD122(+) T cells as a prognostic indicator of pancreatic cancer
por: Teramatsu, Katsuhito, et al.
Publicado: (2022)

FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition
por: Firat, Elke, et al.
Publicado: (2016)

The influence of the combined treatment with Vadimezan (ASA404) and taxol on the growth of U251 glioblastoma xenografts
por: Milanović, Dušan, et al.
Publicado: (2012)

A prospective study of immune responses in patients with lung metastases treated with stereotactic body radiotherapy with or without concurrent systemic treatment
por: Duda, Dan, et al.
Publicado: (2023)

CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival
por: Liu, Huazhen, et al.
Publicado: (2019)

CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation
por: Reyes, Ryan M, et al.
Publicado: (2021)

Essential Roles of CD8(+)CD122(+) Regulatory T Cells in the Maintenance of T Cell Homeostasis
por: Rifa'i, Muhaimin, et al.
Publicado: (2004)

Chinese medicine Ginseng and Astragalus granules ameliorate autoimmune diabetes by upregulating both CD4+FoxP3+ and CD8+CD122+PD1+ regulatory T cells
por: Wang, Yeshu, et al.
Publicado: (2017)

CD122-targetted IL-2 signals cause acute and selective apoptosis of B cells in Peyer’s Patches
por: Singh, Ayushi, et al.
Publicado: (2020)

Rapid and efficient transfer of the T cell aging marker CD57 from glioblastoma stem cells to CAR T cells
por: Zhu, Xuekai, et al.
Publicado: (2015)

Hypoxia dynamics on FMISO-PET in combination with PD-1/PD-L1 expression has an impact on the clinical outcome of patients with Head-and-neck Squamous Cell Carcinoma undergoing Chemoradiation
por: Rühle, Alexander, et al.
Publicado: (2020)

Combination of cancer vaccine with CD122-biased IL-2/anti-IL-2 Ab complex shapes the stem-like effector NK and CD8(+) T cells against tumor
por: Shimizu, Kanako, et al.
Publicado: (2023)

Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
por: Gkika, Eleni, et al.
Publicado: (2023)

An In-Vitro Study of the Expansion and Transcriptomics of CD(4+) and CD(8+) Naïve and Memory T Cells Stimulated by IL-2, IL-7 and IL-15
por: Hopkins, Brooks, et al.
Publicado: (2022)

Synergy of IL-21 and IL-15 in regulating CD8(+) T cell expansion and function
por: Zeng, Rong, et al.
Publicado: (2005)

Herbal Components of a Novel Formula PSORI-CM02 Interdependently Suppress Allograft Rejection and Induce CD8+CD122+PD-1+ Regulatory T Cells
por: Lu, Chuanjian, et al.
Publicado: (2018)

Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis
por: Li, Wenli, et al.
Publicado: (2021)

CD8(+)CD122(+) T-Cells: A Newly Emerging Regulator with Central Memory Cell Phenotypes
por: Liu, Junfeng, et al.
Publicado: (2015)

Resveratrol exerts antitumor effects by downregulating CD8(+)CD122(+) Tregs in murine hepatocellular carcinoma
por: Zhang, Qunfang, et al.
Publicado: (2020)

Baseline Ad5 serostatus does not predict Ad5-HIV vaccine-induced expansion of Ad-specific CD4+ T-cells
por: Hutnick, Natalie A., et al.
Publicado: (2009)

Suppression of allograft rejection by CD8+CD122+PD-1+ Tregs is dictated by their Fas ligand-initiated killing of effector T cells versus Fas-mediated own apoptosis
por: Liu, Huazhen, et al.
Publicado: (2017)

Reduced Expression of PD-1 in Circulating CD4+ and CD8+ Tregs Is an Early Feature of RRMS
por: Machcińska, Maja, et al.
Publicado: (2022)

Circulating memory PD-1(+)CD8(+) T cells and PD-1(+)CD8(+)T/PD-1(+)CD4(+)T cell ratio predict response and outcome to immunotherapy in advanced gastric cancer patients
por: Liu, Jiang, et al.
Publicado: (2023)

IL-21 promotes the expansion of CD27(+)CD28(+) tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells
por: Santegoets, Saskia JAM, et al.
Publicado: (2013)

Targeting of CD122 enhances antitumor immunity by altering the tumor immune environment
por: Villarreal, Daniel O., et al.
Publicado: (2017)

IL-15 Augments TCR-Induced CD4(+) T Cell Expansion In Vitro by Inhibiting the Suppressive Function of CD25(High) CD4(+) T Cells
por: Van Belle, Tom L., et al.
Publicado: (2012)

Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8(+) CD122(+) T Cells
por: Seki, Shuhji, et al.
Publicado: (2011)

Synergistic antitumor activity of the CD122-biased immunostimulatory cytokine NKTR-214 when combined with anti-PD-1 in murine tumor models
por: Murali, Addepalli, et al.
Publicado: (2015)

CXCR3 May Help Regulate the Inflammatory Response in Acute Lung Injury via a Pathway Modulated by IL-10 Secreted by CD8 + CD122+ Regulatory T Cells
por: Nie, Li, et al.
Publicado: (2015)

Circulating Exhausted PD-1(+)CD39(+) Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade
por: Martinez-Gomez, Carlos, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hkovmassie9rfr8gmchjj816kd