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Embryonic keratin19(+) progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla

The thymus medulla is a key site for immunoregulation and tolerance, and its functional specialisation is achieved through the complexity of medullary thymic epithelial cells (mTEC). While the importance of the medulla for thymus function is clear, the production and maintenance of mTEC diversity re...

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Detalles Bibliográficos
Autores principales: Lucas, Beth, White, Andrea J., Klein, Fabian, Veiga-Villauriz, Clara, Handel, Adam, Bacon, Andrea, Cosway, Emilie J., James, Kieran D., Parnell, Sonia M., Ohigashi, Izumi, Takahama, Yousuke, Jenkinson, William E., Hollander, Georg A., Lu, Wei-Yu, Anderson, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097809/
https://www.ncbi.nlm.nih.gov/pubmed/37045811
http://dx.doi.org/10.1038/s41467-023-37589-4