Cargando…

Embryonic keratin19(+) progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla

The thymus medulla is a key site for immunoregulation and tolerance, and its functional specialisation is achieved through the complexity of medullary thymic epithelial cells (mTEC). While the importance of the medulla for thymus function is clear, the production and maintenance of mTEC diversity re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lucas, Beth, White, Andrea J., Klein, Fabian, Veiga-Villauriz, Clara, Handel, Adam, Bacon, Andrea, Cosway, Emilie J., James, Kieran D., Parnell, Sonia M., Ohigashi, Izumi, Takahama, Yousuke, Jenkinson, William E., Hollander, Georg A., Lu, Wei-Yu, Anderson, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097809/ https://www.ncbi.nlm.nih.gov/pubmed/37045811 http://dx.doi.org/10.1038/s41467-023-37589-4

Ejemplares similares

Redefining thymus medulla specialization for central tolerance
por: Cosway, Emilie J., et al.
Publicado: (2017)

Failures in thymus medulla regeneration during immune recovery cause tolerance loss and prime recipients for auto-GVHD
por: Alawam, Abdullah S., et al.
Publicado: (2021)

Formation of the Intrathymic Dendritic Cell Pool Requires CCL21-Mediated Recruitment of CCR7(+) Progenitors to the Thymus
por: Cosway, Emilie J., et al.
Publicado: (2018)

The thymus medulla and its control of αβT cell development
por: Cosway, Emilie J., et al.
Publicado: (2020)

The Role of Proteasomes in the Thymus
por: Frantzeskakis, Melina, et al.
Publicado: (2021)

Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium
por: Ohigashi, Izumi, et al.
Publicado: (2023)

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
por: Lucas, Beth, et al.
Publicado: (2020)

Dynamic spatio‐temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla
por: Mayer, Carlos E., et al.
Publicado: (2016)

The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration
por: Cosway, Emilie J., et al.
Publicado: (2023)

Control of the thymic medulla and its influence on αβT‐cell development
por: Lucas, Beth, et al.
Publicado: (2016)

Postnatal Involution and Counter-Involution of the Thymus
por: Cowan, Jennifer E., et al.
Publicado: (2020)

Border control: Anatomical origins of the thymus medulla
por: Anderson, Graham, et al.
Publicado: (2015)

Lymphotoxin β Receptor Controls T Cell Progenitor Entry to the Thymus
por: Lucas, Beth, et al.
Publicado: (2016)

Eosinophils Are An Essential Element Of A Type 2 Immune Axis That Controls Thymus Regeneration
por: Cosway, Emilie J., et al.
Publicado: (2022)

Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk
por: White, Andrea J., et al.
Publicado: (2023)

Specific impact of β5t on proteasome subunit composition in cortical thymic epithelial cells
por: Ohigashi, Izumi, et al.
Publicado: (2021)

The thymus and rheumatology: should we care?
por: Cosway, Emilie, et al.
Publicado: (2016)

A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node
por: Takeuchi, Arata, et al.
Publicado: (2018)

Foxn1-β5t transcriptional axis controls CD8(+) T-cell production in the thymus
por: Uddin, Muhammad Myn, et al.
Publicado: (2017)

Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
por: Cowan, Jennifer E., et al.
Publicado: (2019)

Identification of the Transgenic Integration Site in Immunodeficient tgε26 Human CD3ε Transgenic Mice
por: Ohigashi, Izumi, et al.
Publicado: (2010)

Serial progression of cortical and medullary thymic epithelial microenvironments
por: Alves, Nuno L, et al.
Publicado: (2014)

Bone marrow origin of Ia-positive cells in the medulla rat thymus
Publicado: (1981)

Differential Requirement for CCR4 and CCR7 during the Development of Innate and Adaptive αβT Cells in the Adult Thymus
por: Cowan, Jennifer E., et al.
Publicado: (2014)

Thymus medulla fosters generation of natural Treg cells, invariant γδ T cells, and invariant NKT cells: What we learn from intrathymic migration
por: Cowan, Jennifer E, et al.
Publicado: (2015)

A type 2 cytokine axis for thymus emigration
por: White, Andrea J., et al.
Publicado: (2017)

Endothelial cells act as gatekeepers for LTβR-dependent thymocyte emigration
por: James, Kieran D., et al.
Publicado: (2018)

The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
por: Cowan, Jennifer E., et al.
Publicado: (2013)

CCR7 Signals Are Essential for Cortex–Medulla Migration of Developing Thymocytes
por: Ueno, Tomoo, et al.
Publicado: (2004)

Keratin 8 Is Required for the Maintenance of Architectural Structure in Thymus Epithelium
por: Odaka, Chikako, et al.
Publicado: (2013)

Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP
por: Jiang, Qi, et al.
Publicado: (2006)

Non-Epithelial Stromal Cells in Thymus Development and Function
por: James, Kieran D., et al.
Publicado: (2021)

Aire controls the recirculation of murine Foxp3(+) regulatory T‐cells back to the thymus
por: Cowan, Jennifer E., et al.
Publicado: (2018)

T‐cell egress from the thymus: Should I stay or should I go?
por: James, Kieran D., et al.
Publicado: (2018)

Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development
por: Fujimori, Sayumi, et al.
Publicado: (2022)

On the Reflex Function of the Medulla Oblongata and Medulla Spinalis
Publicado: (1834)

On the Reflex Function of the Medulla Oblongata and Medulla Spinalis
Publicado: (1834)

IAN Family Critically Regulates Survival and Development of T Lymphocytes
por: Nitta, Takeshi, et al.
Publicado: (2006)

Analysis of the first two waves of thymus homing stem cells and their T cell progeny in chick-quail chimeras
Publicado: (1989)

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
por: Lei, Yu, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_l1g3o0kvph9b1i8qjb46nihlbv