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The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications

Histone lysine methyltransferases (HKMTs) deposit methyl groups onto lysine residues on histones and play important roles in regulating chromatin structure and gene expression. The structures and functions of HKMTs have been extensively investigated in recent decades, significantly advancing our und...

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Detalles Bibliográficos
Autores principales: Li, Yanjing, Ge, Kexue, Li, Tingting, Cai, Run, Chen, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098044/
https://www.ncbi.nlm.nih.gov/pubmed/37051671
http://dx.doi.org/10.1093/procel/pwac032