Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection

A soluble ACE2 protein bioengineered for long duration of action and high affinity to SARS-CoV-2 was administered either intranasally (IN) or intraperitoneally (IP) to SARS-CoV-2–inoculated k18hACE2 mice. This decoy protein (ACE2 618-DDC-ABD) was given either IN or IP, pre- and post-inoculation, or...

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Detalles Bibliográficos
Autores principales: Hassler, Luise, Wysocki, Jan, Ahrendsen, Jared T, Ye, Minghao, Gelarden, Ian, Nicolaescu, Vlad, Tomatsidou, Anastasia, Gula, Haley, Cianfarini, Cosimo, Forster, Peter, Khurram, Nigar, Singer, Benjamin D, Randall, Glenn, Missiakas, Dominique, Henkin, Jack, Batlle, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098141/
https://www.ncbi.nlm.nih.gov/pubmed/37041017
http://dx.doi.org/10.26508/lsa.202301969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098141/
https://www.ncbi.nlm.nih.gov/pubmed/37041017
http://dx.doi.org/10.26508/lsa.202301969

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