Dynamic Covalent Michael Acceptors to Penetrate Cells: Thiol‐Mediated Uptake with Tetrel‐Centered Exchange Cascades, Assisted by Halogen‐Bonding Switches

Chalcogen‐centered cascade exchange chemistry is increasingly understood to account for thiol‐mediated uptake, that is, the ability of reversibly thiol‐reactive agents to penetrate cells. Here, reversible Michael acceptors are shown to enable and inhibit thiol‐mediated uptake, including the cytosoli...

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Detalles Bibliográficos
Autores principales: Shybeka, Inga, Maynard, John R. J., Saidjalolov, Saidbakhrom, Moreau, Dimitri, Sakai, Naomi, Matile, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098706/
https://www.ncbi.nlm.nih.gov/pubmed/36272154
http://dx.doi.org/10.1002/anie.202213433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098706/
https://www.ncbi.nlm.nih.gov/pubmed/36272154
http://dx.doi.org/10.1002/anie.202213433

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