Biosynthesis of Nodulisporic Acids: A Multifunctional Monooxygenase Delivers a Complex and Highly Branched Array

Nodulisporic acids (NAs) are structurally complex potent antiinsectan indole diterpenes. We previously reported the biosynthetic gene cluster for these metabolites in Hypoxylon pulicicidum and functionally characterised the first five steps of the biosynthetic pathway. Here we reveal a highly comple...

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Detalles Bibliográficos
Autores principales: Richardson, Alistair T., Cameron, Rosannah C., Stevenson, Luke J., Singh, A. Jonathan, Lukito, Yonathan, Berry, Daniel, Nicholson, Matthew J., Parker, Emily J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098816/
https://www.ncbi.nlm.nih.gov/pubmed/36199176
http://dx.doi.org/10.1002/anie.202213364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098816/
https://www.ncbi.nlm.nih.gov/pubmed/36199176
http://dx.doi.org/10.1002/anie.202213364

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