Oxidative Desymmetrization Enables the Concise Synthesis of a trans‐Cyclooctene Linker for Bioorthogonal Bond Cleavage

Modified trans‐cyclooctenes (TCO) are capable of highly efficient molecular manipulations in biological environments, driven by the bioorthogonal reaction with tetrazines (Tz). The development of click‐cleavable TCO has fueled the field of in vivo chemistry and enabled the design of therapeutic stra...

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Detalles Bibliográficos
Autores principales: Kuba, Walter, Sohr, Barbara, Keppel, Patrick, Svatunek, Dennis, Humhal, Viktoria, Stöger, Berthold, Goldeck, Marion, Carlson, Jonathan C. T., Mikula, Hannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098836/
https://www.ncbi.nlm.nih.gov/pubmed/36250260
http://dx.doi.org/10.1002/chem.202203069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098836/
https://www.ncbi.nlm.nih.gov/pubmed/36250260
http://dx.doi.org/10.1002/chem.202203069

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