Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin

Mupirocin is a clinically important antibiotic produced by Pseudomonas fluorescens NCIMB 10586 that is assembled by a complex trans‐AT polyketide synthase. The polyketide fragment, monic acid, is esterified by a 9‐hydroxynonanoic acid (9HN) side chain which is essential for biological activity. The...

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Detalles Bibliográficos
Autores principales: Winter, Ashley J., Rowe, Matthew T., Weir, Angus N. M., Akter, Nahida, Mbatha, Sbusisiwe Z., Walker, Paul D., Williams, Christopher, Song, Zhongshu, Race, Paul R., Willis, Christine L., Crump, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098928/
https://www.ncbi.nlm.nih.gov/pubmed/36227272
http://dx.doi.org/10.1002/anie.202212393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098928/
https://www.ncbi.nlm.nih.gov/pubmed/36227272
http://dx.doi.org/10.1002/anie.202212393

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