A flow electrochemistry‐enabled synthesis of 2‐substituted N‐(methyl‐d)piperidines

A synthesis of N‐monodeuteriomethyl‐2‐substituted piperidines is described. An efficient and readily scalable anodic methoxylation of N‐formylpiperidine in an undivided microfluidic electrolysis cell delivers methoxylated piperidine 3, which is a precursor to a N‐formyliminium ion and enables C‐nucl...

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Detalles Bibliográficos
Autores principales: AL‐Hadedi, Azzam A. M., Sawyer, Stuart, Elliott, Stuart J., Green, Robert A., O'Leary, Daniel J., Brown, Richard C. D., Brown, Lynda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098938/
https://www.ncbi.nlm.nih.gov/pubmed/36272110
http://dx.doi.org/10.1002/jlcr.4006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098938/
https://www.ncbi.nlm.nih.gov/pubmed/36272110
http://dx.doi.org/10.1002/jlcr.4006

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