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A flow electrochemistry‐enabled synthesis of 2‐substituted N‐(methyl‐d)piperidines
A synthesis of N‐monodeuteriomethyl‐2‐substituted piperidines is described. An efficient and readily scalable anodic methoxylation of N‐formylpiperidine in an undivided microfluidic electrolysis cell delivers methoxylated piperidine 3, which is a precursor to a N‐formyliminium ion and enables C‐nucl...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098938/ https://www.ncbi.nlm.nih.gov/pubmed/36272110 http://dx.doi.org/10.1002/jlcr.4006 |