Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate‐Containing Natural Products in Diverse Bacteria

Benzoxazolinate is a rare bis‐heterocyclic moiety that interacts with proteins and DNA and confers extraordinary bioactivities on natural products, such as C‐1027. However, the biosynthetic gene responsible for the key cyclization step of benzoxazolinate remains unclear. Herein, we show a putative a...

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Detalles Bibliográficos
Autores principales: Shi, Yi‐Ming, Crames, Jan J., Czech, Laura, Bozhüyük, Kenan A. J., Shi, Yan‐Ni, Hirschmann, Merle, Lamberth, Stefanie, Claus, Peter, Paczia, Nicole, Rückert, Christian, Kalinowski, Jörn, Bange, Gert, Bode, Helge B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098953/
https://www.ncbi.nlm.nih.gov/pubmed/36198080
http://dx.doi.org/10.1002/anie.202206106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098953/
https://www.ncbi.nlm.nih.gov/pubmed/36198080
http://dx.doi.org/10.1002/anie.202206106

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