Design and Synthesis of Covalent Inhibitors of FabA

[Image: see text] There is an urgent need for the development of new therapeutics with novel modes of action to target Gram-negative bacterial infections, due to resistance to current drugs. Previously, FabA, an enzyme in the bacterial type II fatty acid biosynthesis pathway, was identified as a pot...

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Detalles Bibliográficos
Autores principales: Martin, James S., Mackenzie, Claire J., Lin, De, Homeyer, Nadine, Gray, David W., Zuccotto, Fabio, Gilbert, Ian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099128/
https://www.ncbi.nlm.nih.gov/pubmed/37065080
http://dx.doi.org/10.1021/acsomega.2c08031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099128/
https://www.ncbi.nlm.nih.gov/pubmed/37065080
http://dx.doi.org/10.1021/acsomega.2c08031

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