Exploring the Potential of Multinuclear Solid‐State (1)H, (13)C, and (35)Cl Magnetic Resonance To Characterize Static and Dynamic Disorder in Pharmaceutical Hydrochlorides

Crystallographic disorder, whether static or dynamic, can be detrimental to the physical and chemical stability, ease of crystallization and dissolution rate of an active pharmaceutical ingredient. Disorder can result in a loss of manufacturing control leading to batch‐to‐batch variability and can l...

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Detalles Bibliográficos
Autores principales: Szell, Patrick M. J., Rehman, Zainab, Tatman, Ben P., Hughes, Leslie P., Blade, Helen, Brown, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099218/
https://www.ncbi.nlm.nih.gov/pubmed/36195553
http://dx.doi.org/10.1002/cphc.202200558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099218/
https://www.ncbi.nlm.nih.gov/pubmed/36195553
http://dx.doi.org/10.1002/cphc.202200558

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