Design, Synthesis, Computational Investigations, and Antitumor Evaluation of N-Rhodanine Glycosides Derivatives as Potent DNA Intercalation and Topo II Inhibition against Cancer Cells

[Image: see text] Nitrogen and sulfur glycosylation was carried out via the reaction of rhodanine (1) with α-acetobromoglucose 3 under basic conditions. Deacetylation of the protected nitrogen nucleoside 4 was performed with CH(3)ONa in CH(3)OH without cleavage of the rhodanine ring to afford the de...

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Detalles Bibliográficos
Autores principales: Khodair, Ahmed I., Alzahrani, Fatimah M., Awad, Mohamed K., Al-Issa, Siham A., Al-Hazmi, Ghaferah H., Nafie, Mohamed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099454/
https://www.ncbi.nlm.nih.gov/pubmed/37065038
http://dx.doi.org/10.1021/acsomega.3c00641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099454/
https://www.ncbi.nlm.nih.gov/pubmed/37065038
http://dx.doi.org/10.1021/acsomega.3c00641

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