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Synaptic Loss in Frontotemporal Dementia Revealed by [ (11)C]UCB‐J Positron Emission Tomography

OBJECTIVE: Synaptic loss is an early feature of neurodegenerative disease models, and is severe in post mortem clinical studies, including frontotemporal dementia. Positron emission tomography (PET) with radiotracers that bind to synaptic vesicle glycoprotein 2A enables quantification of synaptic de...

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Detalles Bibliográficos
Autores principales: Malpetti, Maura, Jones, P. Simon, Cope, Thomas E., Holland, Negin, Naessens, Michelle, Rouse, Matthew A., Rittman, Timothy, Savulich, George, Whiteside, David J., Street, Duncan, Fryer, Tim D., Hong, Young T., Milicevic Sephton, Selena, Aigbirhio, Franklin I., O′Brien, John T., Rowe, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099663/
https://www.ncbi.nlm.nih.gov/pubmed/36321699
http://dx.doi.org/10.1002/ana.26543