Substrate Induced Movement of the Metal Cofactor between Active and Resting State

Regulation of enzyme activity is vital for living organisms. In metalloenzymes, far‐reaching rearrangements of the protein scaffold are generally required to tune the metal cofactor's properties by allosteric regulation. Here structural analysis of hydroxyketoacid aldolase from Sphingomonas wit...

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Detalles Bibliográficos
Autores principales: Marsden, Stefan R., Wijma, Hein J., Mohr, Michael K. F., Justo, Inês, Hagedoorn, Peter‐Leon, Laustsen, Jesper, Jeffries, Cy M., Svergun, Dmitri, Mestrom, Luuk, McMillan, Duncan G. G., Bento, Isabel, Hanefeld, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099721/
https://www.ncbi.nlm.nih.gov/pubmed/36214476
http://dx.doi.org/10.1002/anie.202213338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099721/
https://www.ncbi.nlm.nih.gov/pubmed/36214476
http://dx.doi.org/10.1002/anie.202213338

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