Rational Design and Synthesis of D‐galactosyl Lysophospholipids as Selective Substrates and non‐ATP‐competitive Inhibitors of Phosphatidylinositol Phosphate Kinases

Phosphatidylinositol phosphate kinases (PIPKs) produce lipid signaling molecules and have been attracting increasing attention as drug targets for cancer, neurodegenerative diseases, and viral infection. Given the potential cross‐inhibition of kinases and other ATP‐utilizing enzymes by ATP‐competiti...

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Detalles Bibliográficos
Autores principales: Sun, Mengxia, Zhang, Chi, Sui, Dexin, Yang, Canchai, Pyeon, Dohun, Huang, Xuefei, Hu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099810/
https://www.ncbi.nlm.nih.gov/pubmed/36424188
http://dx.doi.org/10.1002/chem.202202083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099810/
https://www.ncbi.nlm.nih.gov/pubmed/36424188
http://dx.doi.org/10.1002/chem.202202083

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