Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review

The OECD Test Guideline 488 (TG 488) for the Transgenic Rodent Gene Mutation Assay has undergone several revisions to update the recommended design for studying mutations in somatic tissues and male germ cells. The recently revised TG recommends a single sampling time of 28 days following 28 days of...

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Detalles Bibliográficos
Autores principales: Douglas, George R., Beevers, Carol, Gollapudi, Bhaskar, Keig‐Shevlin, Zena, Kirkland, David, O'Brien, Jason M., van Benthem, Jan, Yauk, Carole L., Young, Robert R., Marchetti, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099936/
https://www.ncbi.nlm.nih.gov/pubmed/36271823
http://dx.doi.org/10.1002/em.22514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099936/
https://www.ncbi.nlm.nih.gov/pubmed/36271823
http://dx.doi.org/10.1002/em.22514

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