Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Allosteric Binding Site of GPCRs

A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein‐coupled receptors (GPCRs). Ligands targeting the IABS, so‐called intracellular allosteric antagonists, are highly promising compounds for pharmaceutical intervention and currently evaluated in...

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Detalles Bibliográficos
Autores principales: Huber, Max E., Toy, Lara, Schmidt, Maximilian F., Weikert, Dorothee, Schiedel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Concepts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100284/
https://www.ncbi.nlm.nih.gov/pubmed/36193681
http://dx.doi.org/10.1002/chem.202202565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100284/
https://www.ncbi.nlm.nih.gov/pubmed/36193681
http://dx.doi.org/10.1002/chem.202202565

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