Native Top‐Down Mass Spectrometry Reveals a Role for Interfacial Glycans on Therapeutic Cytokine and Hormone Assemblies

Oligomerization and glycosylation modulate therapeutic glycoprotein stability and efficacy. The interplay between these two critical attributes on therapeutic glycoproteins, is however often hard to define. Here, we present a native top‐down mass spectrometry (MS) approach to assess the glycosylatio...

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Detalles Bibliográficos
Autores principales: Wu, Di, Robinson, Carol V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100379/
https://www.ncbi.nlm.nih.gov/pubmed/36260431
http://dx.doi.org/10.1002/anie.202213170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100379/
https://www.ncbi.nlm.nih.gov/pubmed/36260431
http://dx.doi.org/10.1002/anie.202213170

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