The NF-ĸB p50 subunit generated by KPC1-mediated ubiquitination and limited proteasomal processing, suppresses tumor growth

Nuclear factor-ĸB (NF-ĸB) is an important transcriptional regulator of key cellular processes, including cell cycle, immune response, and malignant transformation. We found that the ubiquitin ligase Kip1 ubiquitination-promoting complex subunit 1 (KPC1; also known as Ring finger protein 123 – RNF123...

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Detalles Bibliográficos
Autores principales: Kravtsova-Ivantsiv, Yelena, Goldhirsh, Gilad, Tomuleasa, Ciprian, Pikarsky, Eli, Ciechanover, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100387/
https://www.ncbi.nlm.nih.gov/pubmed/37055826
http://dx.doi.org/10.1186/s12935-023-02919-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100387/
https://www.ncbi.nlm.nih.gov/pubmed/37055826
http://dx.doi.org/10.1186/s12935-023-02919-5

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