Immunopathology of terminal complement activation and complement C5 blockade creating a pro‐survival and organ‐protective phenotype in trauma

BACKGROUND AND PURPOSE: Traumatic haemorrhage (TH) is the leading cause of potentially preventable deaths that occur during the prehospital phase of care. No effective pharmacological therapeutics are available for critical TH patients yet. Here, we identify terminal complement activation (TCA) as a...

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Detalles Bibliográficos
Autores principales: Yang, Zhangsheng, Nunn, Miles A., Le, Tuan D., Simovic, Milomir O., Edsall, Peter R., Liu, Bin, Barr, Johnny L., Lund, Brian J., Hill‐Pryor, Crystal D., Pusateri, Anthony E., Cancio, Leopoldo C., Li, Yansong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100417/
https://www.ncbi.nlm.nih.gov/pubmed/36251578
http://dx.doi.org/10.1111/bph.15970

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