Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics

[Image: see text] In prion diseases, fibrillar assemblies of misfolded prion protein (PrP) self-propagate by incorporating PrP monomers. These assemblies can evolve to adapt to changing environments and hosts, but the mechanism of prion evolution is poorly understood. We show that PrP fibrils exist...

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Detalles Bibliográficos
Autores principales: Sun, Yuanzi, Jack, Kezia, Ercolani, Tiziana, Sangar, Daljit, Hosszu, Laszlo, Collinge, John, Bieschke, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100569/
https://www.ncbi.nlm.nih.gov/pubmed/36802500
http://dx.doi.org/10.1021/acsnano.2c12009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100569/
https://www.ncbi.nlm.nih.gov/pubmed/36802500
http://dx.doi.org/10.1021/acsnano.2c12009

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