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Single Amino Acid Substitution in the Receptor Binding Domain of Spike Protein Is Sufficient To Convert the Neutralization Profile between Ethiopian and Middle Eastern Isolates of Middle East Respiratory Coronavirus

Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes MERS, which is endemic in the Middle East. The absence of human cases in Africa despite the presence of MERS-CoV suggests virological differences between MERS-CoVs in Africa and the Middle East. In fact, in the l...

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Detalles Bibliográficos
Autores principales: Sugimoto, Satoko, Kakizaki, Masatoshi, Kawase, Miyuki, Kawachi, Kengo, Ujike, Makoto, Kamitani, Wataru, Sentsui, Hiroshi, Shirato, Kazuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100835/
https://www.ncbi.nlm.nih.gov/pubmed/36744940
http://dx.doi.org/10.1128/spectrum.04590-22