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Comparative and Functional Analyses Reveal Conserved and Variable Regulatory Systems That Control Lasalocid Biosynthesis in Different Streptomyces Species

Lasalocid, a representative polyether ionophore, has been successfully applied in veterinary medicine and animal husbandry and also displays promising potential for cancer therapy. Nevertheless, the regulatory system governing lasalocid biosynthesis remains obscure. Here, we identified two conserved...

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Detalles Bibliográficos
Autores principales: Liu, Minghao, Wang, Kairui, Wei, Junhong, Liu, Ning, Niu, Guoqing, Tan, Huarong, Huang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100954/
https://www.ncbi.nlm.nih.gov/pubmed/36847561
http://dx.doi.org/10.1128/spectrum.03852-22