Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis

In this work, we sought to develop a TP4-based stapled peptide that can be used to counter polymicrobial sepsis. First, we segregated the TP4 sequence into hydrophobic and cationic/hydrophilic zones and substituted the preferred residue, lysine, as the sole cationic amino acid. These modifications m...

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Detalles Bibliográficos
Autores principales: Yeh, Jih-Chao, Hazam, Prakash Kishore, Hsieh, Chu-Yi, Hsu, Po-Hsien, Lin, Wen-Chun, Chen, Yun-Ru, Li, Chao-Chin, Chen, Jyh-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101059/
https://www.ncbi.nlm.nih.gov/pubmed/36877022
http://dx.doi.org/10.1128/spectrum.03853-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101059/
https://www.ncbi.nlm.nih.gov/pubmed/36877022
http://dx.doi.org/10.1128/spectrum.03853-22

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