Cargando…

Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes

Ebola virus (EBOV) causes a severe infection called Ebola virus disease (EVD). The pathogenesis of EBOV infection is complex, and outcome has been associated with a variety of immunological and cellular factors. Disease can result from several mechanisms, including direct organ and endothelial cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Xiaofeng, Tree, Julia, Banadyga, Logan, He, Shihua, Zhu, Wenjun, Tipton, Tom, Gouriet, Jade, Qiu, Xiangguo, Elmore, Michael J., Hall, Yper, Carroll, Miles, Hiscox, Julian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101120/ https://www.ncbi.nlm.nih.gov/pubmed/36946725 http://dx.doi.org/10.1128/spectrum.04154-22

Ejemplares similares

Dose-Dependent Response to Infection with Ebola Virus in the Ferret Model and Evidence of Viral Evolution in the Eye
por: Watson, Robert J., et al.
Publicado: (2021)

The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated With Monoclonal Antibodies
por: Banadyga, Logan, et al.
Publicado: (2019)

The Roles of Ebola Virus Soluble Glycoprotein in Replication, Pathogenesis, and Countermeasure Development
por: Zhu, Wenjun, et al.
Publicado: (2019)

Complement-Mediated Neutralisation Identified in Ebola Virus Disease Survivor Plasma: Implications for Protection and Pathogenesis
por: Mellors, Jack, et al.
Publicado: (2022)

Virus inoculation and treatment regimens for evaluating anti-filovirus monoclonal antibody efficacy in vivo
por: Banadyga, Logan, et al.
Publicado: (2019)

Early transmission and case fatality of Ebola virus at the index site of the 2013–16 west African Ebola outbreak: a cross-sectional seroprevalence survey
por: Timothy, Joseph W S, et al.
Publicado: (2019)

Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors
por: Fan, Pengfei, et al.
Publicado: (2020)

Pseudotyping of VSV with Ebola virus glycoprotein is superior to HIV-1 for the assessment of neutralising antibodies
por: Steeds, Kimberley, et al.
Publicado: (2020)

Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop
por: Banadyga, Logan, et al.
Publicado: (2021)

Taï Forest Virus Does Not Cause Lethal Disease in Ferrets
por: Schiffman, Zachary, et al.
Publicado: (2021)

Identification of a clinical compound losmapimod that blocks Lassa virus entry
por: Zhang, Xiaoyu, et al.
Publicado: (2019)

Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease
por: Dong, Xiaofeng, et al.
Publicado: (2020)

AAV-monoclonal antibody expression protects mice from Ebola virus without impeding the endogenous antibody response to heterologous challenge
por: van Lieshout, Laura P., et al.
Publicado: (2022)

Investigating the Cellular Transcriptomic Response Induced by the Makona Variant of Ebola Virus in Differentiated THP-1 Cells
por: Bosworth, Andrew, et al.
Publicado: (2019)

Ebola virus VP24 interacts with NP to facilitate nucleocapsid assembly and genome packaging
por: Banadyga, Logan, et al.
Publicado: (2017)

Analysis of an Ebola virus disease survivor whose host and viral markers were predictive of death indicates the effectiveness of medical countermeasures and supportive care
por: Bosworth, Andrew, et al.
Publicado: (2021)

Naturally Occurring Single Mutations in Ebola Virus Observably Impact Infectivity
por: Wong, Gary, et al.
Publicado: (2018)

Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity
por: Dowall, Stuart D, et al.
Publicado: (2014)

Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses
por: Dunham, Eric C., et al.
Publicado: (2015)

Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus
por: Liu, Xuan, et al.
Publicado: (2017)

Modeling Ebola Virus Transmission Using Ferrets
por: de La Vega, Marc-Antoine, et al.
Publicado: (2018)

The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection
por: Goldswain, Hannah, et al.
Publicado: (2023)

Comprehensive Functional Analysis of N-Linked Glycans on Ebola Virus GP1
por: Lennemann, Nicholas J., et al.
Publicado: (2014)

Structure of the Ebola virus polymerase complex
por: Yuan, Bin, et al.
Publicado: (2022)

Postexposure Prophylaxis With rVSV-ZEBOV Following Exposure to a Patient With Ebola Virus Disease Relapse in the United Kingdom: An Operational, Safety, and Immunogenicity Report
por: Davis, Chris, et al.
Publicado: (2019)

An Investigation of the Effect of Transfected Defective, Ebola Virus Genomes on Ebola Replication
por: Smither, Sophie J., et al.
Publicado: (2020)

Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes
por: Wawina-Bokalanga, Tony, et al.
Publicado: (2021)

Longitudinal antibody and T cell responses in Ebola virus disease survivors and contacts: an observational cohort study
por: Thom, Ruth, et al.
Publicado: (2020)

Can Ebola virus become endemic in the human population?
por: Wong, Gary, et al.
Publicado: (2015)

Characterization of the catalytic center of the Ebola virus L polymerase
por: Schmidt, Marie Luisa, et al.
Publicado: (2017)

Antiviral Screening of Multiple Compounds against Ebola Virus
por: Dowall, Stuart D., et al.
Publicado: (2016)

A Cloned Recombinant Vesicular Stomatitis Virus-Vectored Marburg Vaccine, PHV01, Protects Guinea Pigs from Lethal Marburg Virus Disease
por: Zhu, Wenjun, et al.
Publicado: (2022)

Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus
por: Tchesnokov, Egor P., et al.
Publicado: (2018)

Role of Key Infectivity Parameters in the Transmission of Ebola Virus Makona in Macaques
por: de La Vega, Marc Antoine, et al.
Publicado: (2021)

Equine-Origin Immunoglobulin Fragments Protect Nonhuman Primates from Ebola Virus Disease
por: Wang, Hualei, et al.
Publicado: (2019)

Ebola GP-Specific Monoclonal Antibodies Protect Mice and Guinea Pigs from Lethal Ebola Virus Infection
por: Qiu, Xiangguo, et al.
Publicado: (2012)

Potent neutralizing monoclonal antibodies against Ebola virus infection
por: Zhang, Qi, et al.
Publicado: (2016)

A comparison of host gene expression signatures associated with infection in vitro by the Makona and Ecran (Mayinga) variants of Ebola virus
por: Bosworth, Andrew, et al.
Publicado: (2017)

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
por: Tchesnokov, Egor P., et al.
Publicado: (2019)

Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector
por: Liu, Guodong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ufooi8sfet09vaqm9k3pnjdj4m