Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding

Phase separation can concentrate biomolecules and accelerate reactions. However, the mechanisms and principles connecting this mesoscale organization to signaling dynamics are difficult to dissect because of the pleiotropic effects associated with disrupting endogenous condensates. To address this l...

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Detalles Bibliográficos
Autores principales: Sang, Dajun, Shu, Tong, Pantoja, Christian F., de Opakua, Alain Ibáñez, Zweckstetter, Markus, Holt, Liam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101210/
https://www.ncbi.nlm.nih.gov/pubmed/36108633
http://dx.doi.org/10.1016/j.molcel.2022.08.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101210/
https://www.ncbi.nlm.nih.gov/pubmed/36108633
http://dx.doi.org/10.1016/j.molcel.2022.08.016

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