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Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding
Phase separation can concentrate biomolecules and accelerate reactions. However, the mechanisms and principles connecting this mesoscale organization to signaling dynamics are difficult to dissect because of the pleiotropic effects associated with disrupting endogenous condensates. To address this l...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101210/ https://www.ncbi.nlm.nih.gov/pubmed/36108633 http://dx.doi.org/10.1016/j.molcel.2022.08.016 |