Cargando…

In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts

Patients with Parkinson’s disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson’s disease simultaneously with magnetic resonance imaging (MRI). Neurom...

Descripción completa

Detalles Bibliográficos
Autores principales: Hwang, Kristy S., Langley, Jason, Tripathi, Richa, Hu, Xiaoping P., Huddleston, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101455/
https://www.ncbi.nlm.nih.gov/pubmed/37053195
http://dx.doi.org/10.1371/journal.pone.0282684
_version_ 1785025520448045056
author Hwang, Kristy S.
Langley, Jason
Tripathi, Richa
Hu, Xiaoping P.
Huddleston, Daniel E.
author_facet Hwang, Kristy S.
Langley, Jason
Tripathi, Richa
Hu, Xiaoping P.
Huddleston, Daniel E.
author_sort Hwang, Kristy S.
collection PubMed
description Patients with Parkinson’s disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson’s disease simultaneously with magnetic resonance imaging (MRI). Neuromelanin-sensitive MRI measures of substantia nigra pars compacta and locus coeruleus volume based on explicit magnetization transfer contrast have been shown to have high scan-rescan reproducibility in controls, but no study has replicated detection of Parkinson’s disease-associated volume loss in substantia nigra pars compacta and locus coeruleus in multiple cohorts with the same methodology. Two separate cohorts of Parkinson’s disease patients and controls were recruited from the Emory Movement Disorders Clinic and scanned on two different MRI scanners. In cohort 1, imaging data from 19 controls and 22 Parkinson’s disease patients were acquired with a Siemens Trio 3 Tesla scanner using a 2D gradient echo sequence with magnetization transfer preparation pulse. Cohort 2 consisted of 33 controls and 39 Parkinson’s disease patients who were scanned on a Siemens Prisma 3 Tesla scanner with a similar imaging protocol. Locus coeruleus and substantia nigra pars compacta volumes were segmented in both cohorts. Substantia nigra pars compacta volume (Cohort 1: p = 0.0148; Cohort 2: p = 0.0011) and locus coeruleus volume (Cohort 1: p = 0.0412; Cohort 2: p = 0.0056) were significantly reduced in the Parkinson’s disease group as compared to controls in both cohorts. This imaging approach robustly detects Parkinson’s disease effects on these structures, indicating that it is a promising marker for neurodegenerative neuromelanin loss.
format Online
Article
Text
id pubmed-10101455
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-101014552023-04-14 In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts Hwang, Kristy S. Langley, Jason Tripathi, Richa Hu, Xiaoping P. Huddleston, Daniel E. PLoS One Research Article Patients with Parkinson’s disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson’s disease simultaneously with magnetic resonance imaging (MRI). Neuromelanin-sensitive MRI measures of substantia nigra pars compacta and locus coeruleus volume based on explicit magnetization transfer contrast have been shown to have high scan-rescan reproducibility in controls, but no study has replicated detection of Parkinson’s disease-associated volume loss in substantia nigra pars compacta and locus coeruleus in multiple cohorts with the same methodology. Two separate cohorts of Parkinson’s disease patients and controls were recruited from the Emory Movement Disorders Clinic and scanned on two different MRI scanners. In cohort 1, imaging data from 19 controls and 22 Parkinson’s disease patients were acquired with a Siemens Trio 3 Tesla scanner using a 2D gradient echo sequence with magnetization transfer preparation pulse. Cohort 2 consisted of 33 controls and 39 Parkinson’s disease patients who were scanned on a Siemens Prisma 3 Tesla scanner with a similar imaging protocol. Locus coeruleus and substantia nigra pars compacta volumes were segmented in both cohorts. Substantia nigra pars compacta volume (Cohort 1: p = 0.0148; Cohort 2: p = 0.0011) and locus coeruleus volume (Cohort 1: p = 0.0412; Cohort 2: p = 0.0056) were significantly reduced in the Parkinson’s disease group as compared to controls in both cohorts. This imaging approach robustly detects Parkinson’s disease effects on these structures, indicating that it is a promising marker for neurodegenerative neuromelanin loss. Public Library of Science 2023-04-13 /pmc/articles/PMC10101455/ /pubmed/37053195 http://dx.doi.org/10.1371/journal.pone.0282684 Text en © 2023 Hwang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hwang, Kristy S.
Langley, Jason
Tripathi, Richa
Hu, Xiaoping P.
Huddleston, Daniel E.
In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts
title In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts
title_full In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts
title_fullStr In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts
title_full_unstemmed In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts
title_short In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts
title_sort in vivo detection of substantia nigra and locus coeruleus volume loss in parkinson’s disease using neuromelanin-sensitive mri: replication in two cohorts
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101455/
https://www.ncbi.nlm.nih.gov/pubmed/37053195
http://dx.doi.org/10.1371/journal.pone.0282684
work_keys_str_mv AT hwangkristys invivodetectionofsubstantianigraandlocuscoeruleusvolumelossinparkinsonsdiseaseusingneuromelaninsensitivemrireplicationintwocohorts
AT langleyjason invivodetectionofsubstantianigraandlocuscoeruleusvolumelossinparkinsonsdiseaseusingneuromelaninsensitivemrireplicationintwocohorts
AT tripathiricha invivodetectionofsubstantianigraandlocuscoeruleusvolumelossinparkinsonsdiseaseusingneuromelaninsensitivemrireplicationintwocohorts
AT huxiaopingp invivodetectionofsubstantianigraandlocuscoeruleusvolumelossinparkinsonsdiseaseusingneuromelaninsensitivemrireplicationintwocohorts
AT huddlestondaniele invivodetectionofsubstantianigraandlocuscoeruleusvolumelossinparkinsonsdiseaseusingneuromelaninsensitivemrireplicationintwocohorts