Cargando…
In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts
Patients with Parkinson’s disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson’s disease simultaneously with magnetic resonance imaging (MRI). Neurom...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101455/ https://www.ncbi.nlm.nih.gov/pubmed/37053195 http://dx.doi.org/10.1371/journal.pone.0282684 |
_version_ | 1785025520448045056 |
---|---|
author | Hwang, Kristy S. Langley, Jason Tripathi, Richa Hu, Xiaoping P. Huddleston, Daniel E. |
author_facet | Hwang, Kristy S. Langley, Jason Tripathi, Richa Hu, Xiaoping P. Huddleston, Daniel E. |
author_sort | Hwang, Kristy S. |
collection | PubMed |
description | Patients with Parkinson’s disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson’s disease simultaneously with magnetic resonance imaging (MRI). Neuromelanin-sensitive MRI measures of substantia nigra pars compacta and locus coeruleus volume based on explicit magnetization transfer contrast have been shown to have high scan-rescan reproducibility in controls, but no study has replicated detection of Parkinson’s disease-associated volume loss in substantia nigra pars compacta and locus coeruleus in multiple cohorts with the same methodology. Two separate cohorts of Parkinson’s disease patients and controls were recruited from the Emory Movement Disorders Clinic and scanned on two different MRI scanners. In cohort 1, imaging data from 19 controls and 22 Parkinson’s disease patients were acquired with a Siemens Trio 3 Tesla scanner using a 2D gradient echo sequence with magnetization transfer preparation pulse. Cohort 2 consisted of 33 controls and 39 Parkinson’s disease patients who were scanned on a Siemens Prisma 3 Tesla scanner with a similar imaging protocol. Locus coeruleus and substantia nigra pars compacta volumes were segmented in both cohorts. Substantia nigra pars compacta volume (Cohort 1: p = 0.0148; Cohort 2: p = 0.0011) and locus coeruleus volume (Cohort 1: p = 0.0412; Cohort 2: p = 0.0056) were significantly reduced in the Parkinson’s disease group as compared to controls in both cohorts. This imaging approach robustly detects Parkinson’s disease effects on these structures, indicating that it is a promising marker for neurodegenerative neuromelanin loss. |
format | Online Article Text |
id | pubmed-10101455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-101014552023-04-14 In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts Hwang, Kristy S. Langley, Jason Tripathi, Richa Hu, Xiaoping P. Huddleston, Daniel E. PLoS One Research Article Patients with Parkinson’s disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson’s disease simultaneously with magnetic resonance imaging (MRI). Neuromelanin-sensitive MRI measures of substantia nigra pars compacta and locus coeruleus volume based on explicit magnetization transfer contrast have been shown to have high scan-rescan reproducibility in controls, but no study has replicated detection of Parkinson’s disease-associated volume loss in substantia nigra pars compacta and locus coeruleus in multiple cohorts with the same methodology. Two separate cohorts of Parkinson’s disease patients and controls were recruited from the Emory Movement Disorders Clinic and scanned on two different MRI scanners. In cohort 1, imaging data from 19 controls and 22 Parkinson’s disease patients were acquired with a Siemens Trio 3 Tesla scanner using a 2D gradient echo sequence with magnetization transfer preparation pulse. Cohort 2 consisted of 33 controls and 39 Parkinson’s disease patients who were scanned on a Siemens Prisma 3 Tesla scanner with a similar imaging protocol. Locus coeruleus and substantia nigra pars compacta volumes were segmented in both cohorts. Substantia nigra pars compacta volume (Cohort 1: p = 0.0148; Cohort 2: p = 0.0011) and locus coeruleus volume (Cohort 1: p = 0.0412; Cohort 2: p = 0.0056) were significantly reduced in the Parkinson’s disease group as compared to controls in both cohorts. This imaging approach robustly detects Parkinson’s disease effects on these structures, indicating that it is a promising marker for neurodegenerative neuromelanin loss. Public Library of Science 2023-04-13 /pmc/articles/PMC10101455/ /pubmed/37053195 http://dx.doi.org/10.1371/journal.pone.0282684 Text en © 2023 Hwang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hwang, Kristy S. Langley, Jason Tripathi, Richa Hu, Xiaoping P. Huddleston, Daniel E. In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts |
title | In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts |
title_full | In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts |
title_fullStr | In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts |
title_full_unstemmed | In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts |
title_short | In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts |
title_sort | in vivo detection of substantia nigra and locus coeruleus volume loss in parkinson’s disease using neuromelanin-sensitive mri: replication in two cohorts |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101455/ https://www.ncbi.nlm.nih.gov/pubmed/37053195 http://dx.doi.org/10.1371/journal.pone.0282684 |
work_keys_str_mv | AT hwangkristys invivodetectionofsubstantianigraandlocuscoeruleusvolumelossinparkinsonsdiseaseusingneuromelaninsensitivemrireplicationintwocohorts AT langleyjason invivodetectionofsubstantianigraandlocuscoeruleusvolumelossinparkinsonsdiseaseusingneuromelaninsensitivemrireplicationintwocohorts AT tripathiricha invivodetectionofsubstantianigraandlocuscoeruleusvolumelossinparkinsonsdiseaseusingneuromelaninsensitivemrireplicationintwocohorts AT huxiaopingp invivodetectionofsubstantianigraandlocuscoeruleusvolumelossinparkinsonsdiseaseusingneuromelaninsensitivemrireplicationintwocohorts AT huddlestondaniele invivodetectionofsubstantianigraandlocuscoeruleusvolumelossinparkinsonsdiseaseusingneuromelaninsensitivemrireplicationintwocohorts |