Synonymous alterations of cancer-associated Trp53 CpG mutational hotspots cause fatal developmental jaw malocclusions but no tumors in knock-in mice

Intragenic CpG dinucleotides are tightly conserved in evolution yet are also vulnerable to methylation-dependent mutation, raising the question as to why these functionally critical sites have not been deselected by more stable coding sequences. We previously showed in cell lines that altered exonic...

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Detalles Bibliográficos
Autores principales: Epstein, Richard J., Lin, Frank P. Y., Brink, Robert A., Blackburn, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101519/
https://www.ncbi.nlm.nih.gov/pubmed/37053216
http://dx.doi.org/10.1371/journal.pone.0284327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101519/
https://www.ncbi.nlm.nih.gov/pubmed/37053216
http://dx.doi.org/10.1371/journal.pone.0284327

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