Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus

Otopetrin proteins (OTOPs) form proton-selective ion channels that are expressed in diverse cell types where they mediate detection of acids or regulation of pH. In vertebrates there are three family members: OTOP1 is required for formation of otoconia in the vestibular system and it forms the recep...

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Detalles Bibliográficos
Autores principales: Teng, Bochuan, Kaplan, Joshua P, Liang, Ziyu, Chyung, Kevin Saejin, Goldschen-Ohm, Marcel P, Liman, Emily R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101688/
https://www.ncbi.nlm.nih.gov/pubmed/37053086
http://dx.doi.org/10.7554/eLife.85317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101688/
https://www.ncbi.nlm.nih.gov/pubmed/37053086
http://dx.doi.org/10.7554/eLife.85317

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