Transgenic IDH2(R172K) and IDH2(R140Q) zebrafish models recapitulated features of human acute myeloid leukemia

Isocitrate dehydrogenase 2 (IDH2) mutations occur in more than 15% of cytogenetically normal acute myeloid leukemia (CN-AML) but comparative studies of their roles in leukemogenesis have been scarce. We generated zebrafish models of IDH2(R172K) and IDH2(R140Q) AML and reported their pathologic, func...

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Detalles Bibliográficos
Autores principales: Wang, Dandan, Zheng, Lichuan, Cheng, Bowie Yik Ling, Sin, Chun-Fung, Li, Runsheng, Tsui, Sze Pui, Yi, Xinyu, Ma, Alvin Chun Hang, He, Bai Liang, Leung, Anskar Yu Hung, Sun, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101851/
https://www.ncbi.nlm.nih.gov/pubmed/36739363
http://dx.doi.org/10.1038/s41388-023-02611-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101851/
https://www.ncbi.nlm.nih.gov/pubmed/36739363
http://dx.doi.org/10.1038/s41388-023-02611-y

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