Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA’s role in regulating miR-999

MicroRNAs (miRNA) load onto AGO proteins to target mRNAs for translational repression or degradation. However, miRNA degradation can be triggered when extensively base-paired with target RNAs, which induces confirmational change of AGO and recruitment of ZSWIM8 ubiquitin ligase to mark AGO for prote...

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Detalles Bibliográficos
Autores principales: Sheng, Peike, Li, Lu, Li, Tianqi, Wang, Yuzhi, Hiers, Nicholas M., Mejia, Jennifer S., Sanchez, Jossie S., Zhou, Lei, Xie, Mingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102002/
https://www.ncbi.nlm.nih.gov/pubmed/37055443
http://dx.doi.org/10.1038/s41467-023-37819-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102002/
https://www.ncbi.nlm.nih.gov/pubmed/37055443
http://dx.doi.org/10.1038/s41467-023-37819-9

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