Development of pathway-oriented screening to identify compounds to control 2-methylglyoxal metabolism in tumor cells

Controlling tumor-specific alterations in metabolic pathways is a useful strategy for treating tumors. The glyoxalase pathway, which metabolizes the toxic electrophile 2-methylglyoxal (MG), is thought to contribute to tumor pathology. We developed a live cell-based high-throughput screening system t...

Descripción completa

Detalles Bibliográficos
Autores principales: Yanagi, Kouichi, Komatsu, Toru, Fujikawa, Yuuta, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Ueno, Tasuku, Hanaoka, Kenjiro, Urano, Yasuteru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102174/
https://www.ncbi.nlm.nih.gov/pubmed/37055561
http://dx.doi.org/10.1038/s42004-023-00864-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102174/
https://www.ncbi.nlm.nih.gov/pubmed/37055561
http://dx.doi.org/10.1038/s42004-023-00864-y

Ejemplares similares