PGLYRP1-mIgG2a-Fc inhibits macrophage activation via AKT/NF-κB signaling and protects against fatal lung injury during bacterial infection

Severe bacterial pneumonia leads to acute respiratory distress syndrome (ARDS), with a high incidence rate and mortality. It is well-known that continuous and dysregulated macrophage activation is vital for aggravating the progression of pneumonia. Here, we designed and produced an antibody-like mol...

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Detalles Bibliográficos
Autores principales: Jia, Yan, Ren, Shan, Song, Luyao, Wang, Siyi, Han, Wei, Li, Jingjing, Yu, Yan, Ma, BuYong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102533/
https://www.ncbi.nlm.nih.gov/pubmed/37113764
http://dx.doi.org/10.1016/j.isci.2023.106653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102533/
https://www.ncbi.nlm.nih.gov/pubmed/37113764
http://dx.doi.org/10.1016/j.isci.2023.106653

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