CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis

CD28 and CTLA4 are T cell coreceptors that competitively engage B7 ligands CD80 and CD86 to control adaptive immune responses. While the role of CTLA4 in restraining CD28 costimulatory signaling is well-established, the mechanism has remained unclear. Here, we report that human T cells acquire antig...

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Detalles Bibliográficos
Autores principales: Xu, Xiaozheng, Dennett, Preston, Zhang, Jibin, Sherrard, Alice, Zhao, Yunlong, Masubuchi, Takeya, Bui, Jack D., Chen, Xu, Hui, Enfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103642/
https://www.ncbi.nlm.nih.gov/pubmed/37042938
http://dx.doi.org/10.1084/jem.20221391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103642/
https://www.ncbi.nlm.nih.gov/pubmed/37042938
http://dx.doi.org/10.1084/jem.20221391

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