Stabilization of Interdomain Interactions in G protein α(i) Subunits Determines Gα(i) Subtype Signaling Specificity

Highly homologous members of the Gα(i) family, Gα(i1–3), have distinct tissue distributions and physiological functions, yet the functional properties of these proteins with respect to GDP/GTP binding and regulation of adenylate cyclase are very similar. We recently identified PDZ-RhoGEF (PRG) as a...

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Detalles Bibliográficos
Autores principales: Lefevre, Tyler J., Wei, Wenyuan, Mukhaleva, Elizaveta, Venkata, Sai Pranathi Meda, Chandan, Naincy R., Abraham, Saji, Li, Yong, Dessauer, Carmen W., Vaidehi, Nagarajan, Smrcka, Alan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103935/
https://www.ncbi.nlm.nih.gov/pubmed/37066214
http://dx.doi.org/10.1101/2023.03.10.532072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103935/
https://www.ncbi.nlm.nih.gov/pubmed/37066214
http://dx.doi.org/10.1101/2023.03.10.532072

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